A transition official confirmed to The Washington Post on Monday night that Trump was expected to tap the Reagan administration veteran for the position. His nomination is expected to be formally announced as early as Tuesday.
Lighthizer, who served as deputy U.S. trade representative under President Ronald Reagan, has been the leading candidate for the position for some time, according to The Wall Street Journal.
In his role, Lighthizer will be part of a team responsible for executing on the agenda outlined by Trump on confronting China and Mexico over trade issues, a major component of his populist campaign.
The position is one of four major spots left in Trump's Cabinet, along with secretaries of Veterans Affairs and Agriculture as well as chairman of the Council of Economic Advisers.