She was scheduled to tour the Pyramids and the Great Sphinx before leaving for the United States later on Saturday.
Melania Trump wore slacks and a tie as she stepped off the plane in Cairo, where she proceeded to the presidential palace.
In a Facebook post on Friday, Egypt's First Lady welcomed Melania by saying she would arrive in her "second country, Egypt."
"I am honoured to meet the honourable lady, the wife of the American president, in Cairo tomorrow, and to wish her a successful and happy stay in her second country, Egypt," she wrote in Arabic.
Trump, who also traveled to Malawi and Ghana on her trip, has focused on her signature issue of advocating for children with stops at a hospital, primary school